Nuclear transplantation; cloning
We are trying to find ways of obtaining embryo cells from the cells of an adult. The eventual aim is to provide replacement cells of all kinds starting from usually obtainable cells of an adult individual. For example, we would like to be able to find a way of obtaining spare heart or brain cells from skin or blood cells. The important point is that the replacement cells need to be from the same individual, to avoid problems of rejection and hence of the need for immunosuppression. We are trying to identify the molecules and mechanisms by which eggs can reverse the process of specialisation, so as to derive embryo cells from adult skin cells.